| Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography. | |
| | |
MedLine Citation:
|
PMID: 11527601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to evaluate if there is an association between the antithyroid drug dose that is needed to establish euthyroidism and thyroid blood flow measurements. A total of 23 Graves' disease patients with euthyroidism taking antithyroid drug therapy were enlisted to undergo spectral duplex sonography of the thyroid arteries and color-flow mapping of the thyroid gland. Color pixel density (CPD) was calculated with computer assistance from the color-flow maps. There was a strong correlation between the CPD and methimazole dose (rp = 0.79). Methimazole maintenance dosage could be predicted from CPD values with a coefficient of determination of 0.62. In conclusion, CPD measurements could be a useful tool for the clinical endocrinologist to estimate the antithyroid drug dose that is needed to maintain euthyroidism. |
| | |
Authors:
|
A Saleh; G Fürst; J Feldkamp; E Godehardt; A Grust; U Mödder |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 27 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2001 Aug |
Date Detail:
|
Created Date: 2001-08-30 Completed Date: 2001-10-25 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 1137-41 Citation Subset: IM |
Affiliation:
|
Institute of Diagnostic Radiology, Heinrich Heine University, Düsseldorf, Germany. saleh@uni-duesseldorf.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antithyroid Agents / administration & dosage*, therapeutic use Female Graves Disease / drug therapy*, ultrasonography Humans Male Methimazole / administration & dosage*, therapeutic use Regional Blood Flow Thyroid Gland / blood supply*, ultrasonography* Ultrasonography, Doppler, Color* |
| Chemical | |
Reg. No./Substance:
|
0/Antithyroid Agents; 60-56-0/Methimazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-guided reduction of an incarcerated Spigelian hernia.
Next Document: Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging.