Document Detail


Estimation of aneurysm wall stresses created by treatment with a shape memory polymer foam device.
MedLine Citation:
PMID:  21901546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, compliant latex thin-walled aneurysm models are fabricated to investigate the effects of expansion of shape memory polymer foam. A simplified cylindrical model is selected for the in-vitro aneurysm, which is a simplification of a real, saccular aneurysm. The studies are performed by crimping shape memory polymer foams, originally 6 and 8 mm in diameter, and monitoring the resulting deformation when deployed into 4-mm-diameter thin-walled latex tubes. The deformations of the latex tubes are used as inputs to physical, analytical, and computational models to estimate the circumferential stresses. Using the results of the stress analysis in the latex aneurysm model, a computational model of the human aneurysm is developed by changing the geometry and material properties. The model is then used to predict the stresses that would develop in a human aneurysm. The experimental, simulation, and analytical results suggest that shape memory polymer foams have potential of being a safe treatment for intracranial saccular aneurysms. In particular, this work suggests oversized shape memory foams may be used to better fill the entire aneurysm cavity while generating stresses below the aneurysm wall breaking stresses.
Authors:
Wonjun Hwang; Brent L Volk; Farida Akberali; Pooja Singhal; John C Criscione; Duncan J Maitland
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-09-08
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  11     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-22     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  715-29     Citation Subset:  IM; S    
Affiliation:
Department of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
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MeSH Terms
Descriptor/Qualifier:
Aneurysm / physiopathology*
Humans
Latex
Models, Theoretical
Polymers*
Stress, Physiological*
Grant Support
ID/Acronym/Agency:
R01 EB000462-09/EB/NIBIB NIH HHS; R01 EB000462-10/EB/NIBIB NIH HHS; R01EB000462/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Latex; 0/Polymers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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