| Estimation of amino acid pairs sensitive to variants in human phenylalanine hydroxylase protein by means of a random approach. | |
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MedLine Citation:
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PMID: 12535686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this data-based theoretical analysis, we use a random approach to estimate amino acid pairs in human phenylalanine 4-hydroxylase (PAH) protein in order to determine which amino acid pairs are more sensitive to 187 variants in human PAH protein. The rationale of this study is based on our hypothesis and previous findings that the harmful variants are more likely to occur at randomly unpredictable amino acid pairs rather than at randomly predictable pairs. This is reasonable to argue as randomly predictable amino acid pairs are less likely to be deliberately evolved, whereas randomly unpredictable amino acid pairs are probably deliberately evolved in connection with protein function. 94.12% of 187 variants occurred at randomly unpredictable amino acid pairs, which accounted for 71.84% of 451 amino acid pairs in human PAH protein. The chance of a variant occurring is five times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, randomly unpredictable amino acid pairs are more sensitive to variance in human PAH protein. The results also suggest that the human PAH protein has a natural tendency towards variants. |
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Authors:
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Guang Wu; Shaomin Yan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Peptides Volume: 23 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-21 Completed Date: 2003-08-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 2085-90 Citation Subset: IM |
Affiliation:
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Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France. hongguanglishibahao@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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physiology* Computational Biology Genetic Variation Humans Phenylalanine Hydroxylase / genetics, physiology* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; EC 1.14.16.1/Phenylalanine Hydroxylase |
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