Document Detail


Estimation of amino acid pairs sensitive to variants in human phenylalanine hydroxylase protein by means of a random approach.
MedLine Citation:
PMID:  12535686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this data-based theoretical analysis, we use a random approach to estimate amino acid pairs in human phenylalanine 4-hydroxylase (PAH) protein in order to determine which amino acid pairs are more sensitive to 187 variants in human PAH protein. The rationale of this study is based on our hypothesis and previous findings that the harmful variants are more likely to occur at randomly unpredictable amino acid pairs rather than at randomly predictable pairs. This is reasonable to argue as randomly predictable amino acid pairs are less likely to be deliberately evolved, whereas randomly unpredictable amino acid pairs are probably deliberately evolved in connection with protein function. 94.12% of 187 variants occurred at randomly unpredictable amino acid pairs, which accounted for 71.84% of 451 amino acid pairs in human PAH protein. The chance of a variant occurring is five times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, randomly unpredictable amino acid pairs are more sensitive to variance in human PAH protein. The results also suggest that the human PAH protein has a natural tendency towards variants.
Authors:
Guang Wu; Shaomin Yan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  23     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-08-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2085-90     Citation Subset:  IM    
Affiliation:
Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France. hongguanglishibahao@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / physiology*
Computational Biology
Genetic Variation
Humans
Phenylalanine Hydroxylase / genetics,  physiology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amino Acids; EC 1.14.16.1/Phenylalanine Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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