| Estimation of VLDL, IDL, LDL, HDL2, apoA-I, and apoB from the Friedewald inputs--apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes. | |
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MedLine Citation:
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PMID: 19412820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is an unmet need for a straightforward and cost-effective assessment of multiple lipoprotein risk factors for vascular diseases. AIMS: 1) To study the relation of various lipoprotein lipid and apolipoprotein (apo) measures on the Friedewald inputs, i.e. plasma triglycerides (TG), cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C). 2) To build up regression models for the appropriate measures based solely on the Friedewald inputs. METHODS: Data were available for 1,775 plasma samples, from which very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), and HDL were also isolated by ultracentrifugation. For HDL(2)-C and apolipoproteins, 343 and 247 samples were available, respectively. RESULTS: Accurate models were obtained for VLDL-TG (cross-validation r=0.98), LDL-C (r=0.91), HDL(2)-C (r=0.92), apoA-I (r=0.92), and apoB (r=0.95). A semi-quantitative model was obtained for IDL-C (r=0.78). Due to the anticipated role of IDL-C in atherosclerosis, it was still kept within the accepted models and pursued further. The associations of the estimates with premature deaths were studied in 4,084 patients with type 1 diabetes. The associations of IDL-C and LDL-C were markedly different, the best predictors of mortality being apoB, apoB to apoA-I ratio, and IDL-C. CONCLUSIONS: The new models allow identification of clinically relevant lipoprotein profiles with no added cost to the conventional Friedewald formula. |
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Authors:
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Jaakko Niemi; Ville-Petteri Mäkinen; Jukka Heikkonen; Leena Tenkanen; Yrjö Hiltunen; Minna L Hannuksela; Matti Jauhiainen; Carol Forsblom; Marja-Riitta Taskinen; Y Antero Kesäniemi; Markku J Savolainen; Kimmo Kaski; Per-Henrik Groop; Petri T Kovanen; Mika Ala-Korpela |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of medicine Volume: 41 ISSN: 1365-2060 ISO Abbreviation: Ann. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: England |
Other Details:
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Languages: eng Pagination: 451-61 Citation Subset: IM |
Affiliation:
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Computational Medicine Research Group, Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Cardiovascular Diseases / epidemiology*, etiology Cholesterol / blood, metabolism Diabetes Mellitus, Type 1 / blood*, complications, mortality* Dyslipidemias / complications Humans Lipoproteins / blood*, metabolism Models, Statistical Regression Analysis Risk Assessment Triglycerides / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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