Document Detail

Estimation of total incremental health care costs in patients with atrial fibrillation in the United States.
MedLine Citation:
PMID:  21540439     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Detailed information on the cost burden of atrial fibrillation (AF) is limited. To provide an up-to-date estimate of the national cost of AF, we conducted a retrospective, observational cohort study using administrative claims from the MarketScan Commercial and Medicare Supplemental research data bases, 2004 to 2006.
METHODS AND RESULTS: Patients aged ≥20 years with ≥1 inpatient or ≥2 outpatient AF diagnoses in 2005 (first diagnosis=index) and ≥12 months' enrollment before and after index were selected. AF patients were propensity score-matched (1:1) with non-AF control subjects. Medical costs (2008 US$), including AF costs, other cardiovascular, and noncardiovascular costs, were examined over 1 year after index. National incremental costs of AF were based on age-/sex-specific AF prevalence projections for 2010. In total, 89 066 AF patients were matched to non-AF control subjects. Over 1 year, 37.5% of AF versus 17.5% of control subjects were hospitalized and 2.1% versus 0.1% died during hospitalization. For AF versus control subjects, mean annual inpatient costs per patient were $7841 versus $2622 (incremental cost, $5218), outpatient medical costs were $9225 versus $5629 ($3596), and outpatient pharmacy costs were $3605 versus $3714 (-$109) (all P<0.001). The total incremental cost of AF was $8705 per patient. The national incremental cost of AF was $26.0 billion (AF, $6.0 billion; other cardiovascular, $9.9 billion; noncardiovascular, $10.1 billion). Cardiovascular costs were based on claims with a primary disease diagnosis and may be underestimates.
CONCLUSIONS: On the basis of current US age- and sex-specific prevalence data, the national incremental AF cost is estimated to range from $6.0 to $26.0 billion.
Michael H Kim; Stephen S Johnston; Bong-Chul Chu; Mehul R Dalal; Kathy L Schulman
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Publication Detail:
Type:  Journal Article     Date:  2011-05-03
Journal Detail:
Title:  Circulation. Cardiovascular quality and outcomes     Volume:  4     ISSN:  1941-7705     ISO Abbreviation:  Circ Cardiovasc Qual Outcomes     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-18     Completed Date:  2011-09-30     Revised Date:  2011-10-27    
Medline Journal Info:
Nlm Unique ID:  101489148     Medline TA:  Circ Cardiovasc Qual Outcomes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Division of Cardiology, Northwestern University, Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611, USA.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / economics*,  epidemiology*
Cost of Illness
Health Care Costs / trends*
Hospitalization / economics
Middle Aged
Outcome Assessment (Health Care)
Retrospective Studies
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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