| Estimation of Mouse Organ Locations through Registration of a Statistical Mouse Atlas with Micro-CT Images. | |
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MedLine Citation:
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PMID: 21859613 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Micro-CT is widely used in pre-clinical studies of small animals. Due to the low soft-tissue contrast in typical studies, segmentation of soft tissue organs from non-contrast enhanced micro-CT images is a challenging problem. Here, we propose an atlas-based approach for estimating the major organs in mouse micro-CT images. A statistical atlas of major trunk organs was constructed based on 45 training subjects. The statistical shape model technique was used to include intersubject anatomical variations. The shape correlations between different organs were described using a conditional Gaussian model. For registration, first the high-contrast organs in micro- CT images were registered by fitting the statistical shape model, while the low-contrast organs were subsequently estimated from the high-contrast organs using the conditional Gaussian model. The registration accuracy was validated based on 23 noncontrast- enhanced and 45 contrast-enhanced micro-CT images. Three different accuracy metrics (Dice coefficient, organ volume recovery coefficient and surface distance) were used for evaluation. The Dice coefficients vary from 0.45±0.18 for the spleen to 0.90±0.02 for the lungs, the volume recovery coefficients vary from 0.96±0.10 for the liver to 1.30±0.75 for the spleen, the surface distances vary from 0.18±0.01 mm for the lungs to 0.72±0.42 mm for the spleen. The registration accuracy of the statistical atlas was compared with two publicly available single- subject mouse atlases, i.e. the MOBY phantom and the DIGIMOUSE atlas, and the results proved that the statistical atlas is more accurate than the single atlases. To evaluate the influence of the training subject size, different numbers of training subjects were used for atlas construction and registration. The results showed an improvement of the registration accuracy when more training subjects were used for the atlas construction. The statistical atlas-based registration was also compared with the thin-plate spline based deformable registration, commonly used in mouse atlas registration. Theresults revealed that the statistical atlas has the advantage of improving the estimation of low-contrast organs. |
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Authors:
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H Wang; D Stout; A Chatziiouannou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: IEEE transactions on medical imaging Volume: - ISSN: 1558-0062 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8310780 Medline TA: IEEE Trans Med Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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