Document Detail


Estimation of the Measurement Uncertainty in Quantitative Determination of Ketamine and Norketamine in Urine Using a One-Point Calibration Method.
MedLine Citation:
PMID:  22825634     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An approach was proposed for the estimation of measurement uncertainty for analytical methods based on one-point calibration. The proposed approach is similar to the popular multiple-point calibration approach. However, the standard deviation of calibration was estimated externally. The approach was applied to the estimation of measurement uncertainty for the quantitative determination of ketamine (K) and norketamine (NK) at a 100 ng/mL threshold concentration in urine. In addition to uncertainty due to calibration, sample analysis was the other major source of uncertainty. To include the variation due to matrix effect and temporal effect in sample analysis, different blank urines were spiked with K and NK and analyzed at equal time intervals within and between batches. The expanded uncertainties (k = 2) were estimated to be 10 and 8 ng/mL for K and NK, respectively.
Authors:
Yi-Chun Ma; Che-Wei Wang; Sih-Hua Hung; Yan-Zin Chang; Chia-Reiy Liu; Guor-Rong Her
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  -     ISSN:  1945-2403     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Chemistry, National Taiwan University, No.1, Sec.4, Roosevelt Road, Taipei 10617, Taiwan.
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