Document Detail


Estimation of the LD1 and extrapolation of the LD0.1 for five organophosphate pesticides.
MedLine Citation:
PMID:  1242884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oral LD50,s for organophosphate pesticides have been determined in CD-1 strain male and female mice. The values in mg/kg are: Trichlorfon, 800 and 800; Naled, 409 and 330; Dichlorvos, 139 and 133, GC6506, 23.4 and 17.8; Fospirate, 225 and 263 respectively. Toxicity was greater in males with Fospirate and greater in females with Naled and GC6506. The predicted LD1's and the extrapolated LD0.1's have been determined for the 5 organophosphates from an unbalanced design, loaded heavily toward the lower end of the dose-response curve. It has been shown that the slopes of the curves obtained with 50, 100 and 660 animals are parallel for all compound except Fospirate in the 660 mouse experiments. This is probably related to excessive female deaths in the upper segment of the dose-response curve. Sex dependent lethality was observed with Trichlorfon, Dichlorvos and Fospirate with the males being more susceptible than the females except in the case of Fospirate where there was a reversal at the LD50 with greater susceptibility in the females. The conditions for obtaining accurate results in such experiments have been established. The implications of human exposure to low levels of the environmental pollutants have been discussed.
Authors:
T J Haley; J H Farmer; J R Harmon; K L Dooley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology     Volume:  34     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-02-09     Completed Date:  1976-02-09     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dichlorvos / toxicity
Dose-Response Relationship, Drug
Female
Insecticides / toxicity*
Mice
Mice, Inbred Strains
Naled / toxicity
Organothiophosphorus Compounds
Pyridines / toxicity
Sex Factors
Trichlorfon / toxicity
Chemical
Reg. No./Substance:
0/Insecticides; 0/Organothiophosphorus Compounds; 0/Pyridines; 300-76-5/Naled; 52-68-6/Trichlorfon; 62-73-7/Dichlorvos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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