| Estimation of coronary flow velocity reserve using transthoracic Doppler echocardiography and cold pressor test might be useful for detecting of patients with variant angina. | |
| | |
MedLine Citation:
|
PMID: 20113325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The cold pressor test (CPT) has been used to detect variant angina, but its sensitivity in predicting vasospasm is low. The aim of this study was to determine whether estimates of the coronary flow velocity reserve (CFVR) in the distal left anterior descending coronary artery (dLAD) using transthoracic echocardiography (TTE) and CPT are useful tool to predict variant angina. METHODS: 65 patients (mean age = 52 +/- 10 years; male:female = 41:24) who had normal coronary artery on angiography and underwent acetylcholine provocation test were enrolled and divided into the spasm group (n = 31) and the no spasm group (n = 34). During CPT, the peak (PDV) and mean diastolic flow velocity (MDV) of the dLAD were estimated using TTE with a high-frequency transducer, and electrocardiography, blood pressures, heart rate, and symptoms were monitored every 30 seconds. CPT%PDV and CPT%MDV were defined as the percentage changes in PDV and MDV during CPT, respectively. RESULTS: CPT%PDV was 4.99 +/- 23.62% in the spasm group and 52.75 +/- 24.78% in the no spasm group (P < 0.001). CPT%MDV was 6.83 +/- 23.81% in the spasm group and 50.22 +/- 27.83% in the no spasm group (P < 0.001). CPT%PDV<31.1% had a sensitivity of 93.5% and a specificity of 82.4% in predicting variant angina (95% confidence interval [CI]: 0.939-0.979, P < 0.001). CPT%MDV<30.55% had a sensitivity of 90% and a specificity of 76.5% in predicting variant angina (95% CI: 0.884-0.950, P < 0.001). CONCLUSION: The measurement of changes in the coronary flow velocity of the dLAD using TTE and CPT might be useful for the estimation of endothelial dysfunction in patients with variant angina. |
| | |
Authors:
|
Hui-Jeong Hwang; Woo-Baek Chung; Jeong-Hwan Park; Su-Sung Oh; Jong-Won Chung; Yun-Seok Choi; Ho-Joong Youn |
Related Documents
:
|
17399815 - Myocardial bridging of coronary arteries: a risk factor for myocardial fibrosis? 623015 - Angiographic evaluation of the natural history of normal coronary arteries and mild cor... 17245485 - Acute myocardial infarction and rapid development of coronary aneurysms in a young woma... 8609335 - Ergonovine echocardiography as a screening test for diagnosis of vasospastic angina bef... 7265425 - Cardiac arrhythmias in patients with acute cerebrovascular accidents. 8269315 - The clinical significance of nonsustained ventricular tachycardia. |
Publication Detail:
|
Type: Journal Article Date: 2010-01-22 |
Journal Detail:
|
Title: Echocardiography (Mount Kisco, N.Y.) Volume: 27 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-06-09 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
|
Languages: eng Pagination: 435-41 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angina Pectoris, Variant
/
ultrasonography* Blood Flow Velocity Coronary Angiography / methods Coronary Vessels / ultrasonography* Echocardiography, Doppler / methods* Echocardiography, Stress / methods* Female Humans Male Middle Aged Observer Variation Predictive Value of Tests Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of p53 as predictor for the development of esophageal cancer in achalasia patients.
Next Document: Evaluation of Left Ventricular Circumferential Contraction Functions in Obese Patients.