| Estimating a treatment effect from multidimensional longitudinal data. | |
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MedLine Citation:
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PMID: 9750246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multidimensional longitudinal data result when researchers measure an outcome through time that is quantified by many different response variables. These response variables are often defined on different numerical scales. The objective of this paper is to present a method to summarize and estimate an overall treatment effect from this type of longitudinal data. A regression model is proposed that assumes the treatment effect can be parameterized as an acceleration or deceleration of the time scale of each response variable's trajectory. Generalized estimating equations are used to estimate the model parameters. Cognitive and functional ability data from Alzheimer's disease patients and quality of life data from an AIDS clinical trial are used to illustrate the model. |
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Authors:
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S M Gray; R Brookmeyer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biometrics Volume: 54 ISSN: 0006-341X ISO Abbreviation: Biometrics Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-03 Completed Date: 1998-11-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370625 Medline TA: Biometrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 976-88 Citation Subset: IM; X |
Affiliation:
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Department of Biostatistics, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. gray@jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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psychology,
therapy Alleles Alzheimer Disease / genetics, physiopathology, psychology Apolipoproteins E / genetics Biometry / methods* Clinical Trials as Topic / statistics & numerical data Cognition Data Interpretation, Statistical* Humans Longitudinal Studies* Models, Statistical Quality of Life Regression Analysis Treatment Outcome* |
| Grant Support | |
ID/Acronym/Agency:
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AG05146/AG/NIA NIH HHS; AG08325/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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