Document Detail


Estimating transformations for repeated measures modeling of continuous bounded outcome data.
MedLine Citation:
PMID:  21472758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous bounded outcome data are unlikely to meet the usual assumptions for mixed-effects models of normally distributed and independent subject-specific and residual random effects. Additionally, overly complicated model structures might be necessary to account adequately for non-drug (time-dependent) and drug treatment effects. A transformation strategy with a likelihood component for censoring is developed to promote the simplicity of model structures and to improve the plausibility of assumptions on the random effects. The approach is motivated by Health Assessment Questionnaire Disability Index (HAQ-DI) data from a study in subjects with rheumatoid arthritis and is evaluated using a simulation study.
Authors:
Matthew M Hutmacher; Jonathan L French; Sriram Krishnaswami; Sujatha Menon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-13
Journal Detail:
Title:  Statistics in medicine     Volume:  30     ISSN:  1097-0258     ISO Abbreviation:  Stat Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-07-27     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  935-49     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation:
Ann Arbor Pharmacometrics Group (A2PG), 110 E Miller, Garden Suite, Ann Arbor, MI 48104, USA. matt.hutmacher@a2pg.com
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / drug therapy
Clinical Trials as Topic / methods*
Computer Simulation
Data Interpretation, Statistical*
Humans
Janus Kinase 3 / antagonists & inhibitors
Models, Statistical*
Pyrimidines / administration & dosage,  pharmacology,  therapeutic use
Pyrroles / administration & dosage,  pharmacology,  therapeutic use
Quality of Life
Questionnaires
Treatment Outcome*
Chemical
Reg. No./Substance:
0/Pyrimidines; 0/Pyrroles; 87LA6FU830/tofacitinib; EC 2.7.10.2/Janus Kinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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