Document Detail


Estimating tar and nicotine exposure: human smoking versus machine generated smoke yields.
MedLine Citation:
PMID:  19723554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Determine human smoked (HS) cigarette yields of tar and nicotine for smokers using their own brand in their everyday environment. METHOD: A robust, filter analysis method was used to estimate the tar and nicotine yields for 784 subjects. Seventeen brands were chosen to represent a wide range of styles: 85 and 100 mm lengths; menthol and non-menthol; 17, 23, and 25 mm circumference; with tar yields [Federal Trade Commission (FTC) method] ranging from 1 to 18 mg. Tar bands chosen corresponded to yields of 1-3 mg, 4-6 mg, 7-12 mg, and 13+ mg. RESULTS: A significant difference (p<0.0001) in HS yields of tar and nicotine between tar bands was found. Machine-smoked yields were reasonable predictors of the HS yields for groups of subjects, but the relationship was neither exact nor linear. Neither the FTC, the Massachusetts (MA) nor the Canadian Intensive (CI) machine-smoking methods accurately reflect the HS yields across all brands. The FTC method was closest for the 7-12 mg and 13+ mg products and the MA method was closest for the 1-3mg products. The HS yields for the 4-6 mg products were approximately midway between the FTC and the MA yields. HS nicotine yields corresponded well with published urinary and plasma nicotine biomarker studies.
Authors:
F K St Charles; A A Kabbani; M F Borgerding
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-31
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  56     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-10     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Inc. All rights reserved.
Affiliation:
Formerly of Brown and Williamson Tobacco Company, Macon, GA 31202, USA. kstcharles@bigfoot.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemistry Techniques, Analytical / instrumentation,  standards*
Environmental Exposure
Female
Humans
Male
Nicotine / analysis*
Reproducibility of Results
Smoke / analysis*
Smoking
Tars / analysis*
Tobacco / chemistry*
Chemical
Reg. No./Substance:
0/Smoke; 0/Tars; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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