| Estimating steady-state DLO2 with nonlinear dissociation curves and VA/Q inequality. | |
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MedLine Citation:
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PMID: 3175358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A DLO2 estimate which accounts for the nonlinearity of the oxygen dissociation curve using the Kelman blood gas routines is presented here. The simultaneous differential equations that describe O2 and CO2 diffusion between alveolar gas and pulmonary capillary blood in lung compartments with different VA/Q ratios were solved numerically with a Runge-Kutta algorithm. These integrated estimates were compared to DLO2 estimates that assume the oxygen dissociation curve is linear. In 140 gas exchange data sets from 18 healthy male subjects previously collected at rest and during exercise it was found that DLO2 estimates based on linear dissociation curves exceeded integrated DLO2 estimates by 14, 31, and 55 percent when the PIO2 was 80, 100, and 148 Torr, respectively. We conclude that the linear approximation is accurate when PIO2 is less than 100 Torr but that comparisons of DLO2 estimates at different levels of inspired oxygen must allow for the difference in curvature of the oxygen dissociation curve as a function of PIO2. |
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Authors:
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S C Hempleman; A T Gray |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 73 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-23 Completed Date: 1988-11-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 279-88 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California, San Diego, La Jolla 92093. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Exercise Humans Male Oxyhemoglobins / analysis Partial Pressure Pulmonary Diffusing Capacity* Pulmonary Gas Exchange* |
| Grant Support | |
ID/Acronym/Agency:
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GM07198/GM/NIGMS NIH HHS; HL 33379/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oxyhemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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