| Estimating reference ranges in clinical pathology: an objective approach. | |
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MedLine Citation:
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PMID: 3358017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conventional reference ranges evolve from subjective criteria for health and disease. We offer an objective method for distinguishing typical from atypical values by purely statistical criteria. We define typical values as those exhibiting a linear relationship with percentiles on a value versus percentile plot. Identification of percentiles at which deviation from linearity occurs results from calculation of correlation coefficients between values and percentiles over centrally expanding ranges of percentiles. One selects arbitrarily some minimum value for these correlation coefficients, for example, 0.990, as the criterion for deviation from linearity. Values encompassed by these percentiles of deviation constitute an objective reference range. Identification of any correlations between atypical values and symptoms of disease requires clinical follow-up studies. |
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Authors:
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S Merkouriou; D Dix |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Statistics in medicine Volume: 7 ISSN: 0277-6715 ISO Abbreviation: Stat Med Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-05-16 Completed Date: 1988-05-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8215016 Medline TA: Stat Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 377-85 Citation Subset: IM |
Affiliation:
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Department of Biology and Health Science, University of Hartford, CT 06117. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Enzyme Tests Creatine Kinase / blood Erythrocyte Count Female Humans Male Pathology, Clinical / methods* Reference Values* Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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