Document Detail


Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial.
MedLine Citation:
PMID:  21787883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infertility afflicts 15% of couples who wish to conceive. Despite intensive evaluation of both male and female partners, the etiology may remain unknown leading to a diagnosis of unexplained infertility. For such couples, treatment often entails ovulation induction (OI) with fertility medications coupled with intrauterine insemination. Complications of this therapy include ovarian hyperstimulation syndrome and creation of multiple gestation pregnancies, which can be complicated by preterm labor and delivery, and the associated neonatal morbidity and expense of care for preterm infants. The Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) study is designed to assess whether OI in couples with unexplained infertility with an aromatase inhibitor produces mono-follicular development in most cycles, thereby reducing multiple gestations while maintaining a comparable pregnancy success rate to that achieved by OI with either gonadotropins or clomiphene citrate. These results will provide future guidance of therapy for couples with unexplained infertility, and if comparable pregnancy rates are achieved with a substantial reduction in multiple gestations, the public health benefit will be considerable.
Authors:
Michael P Diamond; Mohamed Mitwally; Robert Casper; Joel Ager; Richard S Legro; Robert Brzyski; Peter Casson; Esther Eisenberg; Heping Zhang;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-07-20
Journal Detail:
Title:  Contemporary clinical trials     Volume:  32     ISSN:  1559-2030     ISO Abbreviation:  Contemp Clin Trials     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-02-02     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  902-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne Sate University, 3800 Woodward Avenue, Suite 320, Detroit, MI 48201, USA. mdiamond@med.wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aromatase Inhibitors / administration & dosage
Clomiphene / administration & dosage*
Dose-Response Relationship, Drug
Double-Blind Method
Female
Fertility Agents, Female / administration & dosage
Gonadotropins / administration & dosage*
Humans
Infant, Newborn
Infertility / drug therapy
Male
Nitriles / administration & dosage*
Ovulation Induction / methods*
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple / statistics & numerical data*
Prospective Studies
Treatment Outcome
Triazoles / administration & dosage*
Young Adult
Grant Support
ID/Acronym/Agency:
3U10 HD 038992-S1/HD/NICHD NIH HHS; 3U10 HD 039005-S1/HD/NICHD NIH HHS; 3U10 HD 055942-S1/HD/NICHD NIH HHS; 3U10 HD 055944-S1/HD/NICHD NIH HHS; 5U10 HD 038992/HD/NICHD NIH HHS; 5U10 HD 039005/HD/NICHD NIH HHS; 5U10 HD 055942/HD/NICHD NIH HHS; 5U10 HD 055944/HD/NICHD NIH HHS; 5U10HD055925/HD/NICHD NIH HHS; 5U10HD055925-S1/HD/NICHD NIH HHS; U10 HD038992/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Fertility Agents, Female; 0/Gonadotropins; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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