Document Detail

Estimating myocardial damage and the need for surgery in patients with valvular heart disease by Tl-201 SPECT.
MedLine Citation:
PMID:  8922847     Owner:  NLM     Status:  MEDLINE    
Left ventricular myocardial disorders due to volume overload were investigated by Tl-201 myocardial SPECT (Tl-201 SPECT) in patients with aortic or mitral regurgitation, and its utility for timing cardiac valve replacement was studied. There were significant correlations between Tl-201 scores and electrocardiographic changes and the New York Heart Association classification. There also were favorable correlations between Tl-201 scores and the left ventricular end-diastolic dimension and between Tl-201 scores and left ventricular ejection fraction, and a close relationship between the presence of a left ventricular myocardial disorder and left ventricular diameter. These results suggest that myocardial perfusion abnormalities and left ventricular myocardial disorders may accompany left ventricular dilatation owing to volume overload. After valve replacement, left ventricular end-diastolic dimension normalized, and Tl-201 scores improved slightly, suggesting normalization of myocardial perfusion. When moderate or more severe Tl-201 defects are present on Tl-201 SPECT images, in addition to inverted Tl-201 waves on the electrocardiogram or a left ventricular end-diastolic dimension of 65 mm or more, cardiac valve replacement should be considered.
J Yamazaki; M Igarashi; M Nakata; K Okamoto; H Hosoi; T Morishita; H Nakano; Y Yabe; K Yoshiwara; N Koyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  21     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-24     Completed Date:  1997-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-63     Citation Subset:  IM    
First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
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MeSH Terms
Aortic Valve Insufficiency / complications*,  physiopathology,  surgery
Cardiomyopathies / diagnosis,  etiology,  radionuclide imaging*
Coronary Circulation
Dipyridamole / diagnostic use
Heart / radionuclide imaging
Heart Valve Prosthesis
Hypertrophy, Left Ventricular / etiology,  radionuclide imaging
Middle Aged
Mitral Valve Insufficiency / complications*,  physiopathology,  surgery
Stroke Volume
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Ventricular Dysfunction, Left / diagnosis,  etiology,  radionuclide imaging
Reg. No./Substance:
0/Thallium Radioisotopes; 58-32-2/Dipyridamole

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