Document Detail


Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation.
MedLine Citation:
PMID:  7153875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination half-life.
Authors:
F L Tse; F Ballard; J Skinn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  10     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Bile / metabolism
Enterohepatic Circulation*
Half-Life
Kinetics
Male
Pharmaceutical Preparations / metabolism*
Rats
Rats, Inbred Strains
Temazepam / metabolism
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; 846-50-4/Temazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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