Document Detail


Estimating consumer exposure to PFOS and PFOA.
MedLine Citation:
PMID:  18419647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfluorinated compounds have been used for more than 50 years as process aids, surfactants, and for surface protection. This study is a comprehensive assessment of consumer exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) from a variety of environmental and product-related sources. To identify relevant pathways leading to consumer exposure to PFOS and PFOA a scenario-based approach has been applied. Scenarios represent realistic situations where age- and gender-specific exposure occurs in the everyday life of consumers. We find that North American and European consumers are likely to experience ubiquitous and long-term uptake doses of PFOS and PFOA in the range of 3 to 220 ng per kg body weight per day (ng/kg(bw)/day) and 1 to 130 ng/kg(bw)/day, respectively. The greatest portion of the chronic exposure to PFOS and PFOA is likely to result from the intake of contaminated foods, including drinking water. Consumer products cause a minor portion of the consumer exposure to PFOS and PFOA. Of these, it is mainly impregnation sprays, treated carpets in homes, and coated food contact materials that may lead to consumer exposure to PFOS and PFOA. Children tend to experience higher total uptake doses (on a body weight basis) than teenagers and adults because of higher relative uptake via food consumption and hand-to-mouth transfer of chemical from treated carpets and ingestion of dust. The uptake estimates based on scenarios are within the range of values derived from blood serum data by applying a one-compartment pharmacokinetic model.
Authors:
David Trudel; Lea Horowitz; Matthias Wormuth; Martin Scheringer; Ian T Cousins; Konrad Hungerbühler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Risk analysis : an official publication of the Society for Risk Analysis     Volume:  28     ISSN:  1539-6924     ISO Abbreviation:  Risk Anal.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-06-20     Revised Date:  2008-09-24    
Medline Journal Info:
Nlm Unique ID:  8109978     Medline TA:  Risk Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-69     Citation Subset:  IM    
Affiliation:
Institute for Chemical and Bioengineering, Wolfgang-Pauli-Str. 10, ETH Zurich, CH-8093 Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Air Pollution, Indoor / analysis
Alkanesulfonic Acids / analysis*,  blood
Child
Child, Preschool
Dust / analysis
Environmental Exposure*
Environmental Monitoring*
Environmental Pollutants / blood*
Female
Fluorocarbons / analysis*,  blood
Humans
Infant
Male
Octanoic Acids / analysis*,  blood
Water Pollutants, Chemical / analysis
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Dust; 0/Environmental Pollutants; 0/Fluorocarbons; 0/Octanoic Acids; 0/Water Pollutants, Chemical; 1763-23-1/perfluorooctane sulfonic acid; 335-67-1/perfluorooctanoic acid
Comments/Corrections
Erratum In:
Risk Anal. 2008 Jun;28(3):807

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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