Document Detail


Estimating concentration of ultrasound contrast agents with backscatter coefficients: experimental and theoretical aspects.
MedLine Citation:
PMID:  22423724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrasound contrast agents (UCAs) have been explored as a means to enhance therapeutic techniques. Because the effectiveness of these techniques relies on the UCA concentration at a target site, it would be beneficial to estimate UCA concentration noninvasively. In this study, a noninvasive method for estimating UCA concentration was developed in vitro. Backscatter coefficients (BSCs) estimated from measurements of Definity(®) UCAs were fitted to a theoretical scattering model in the 15-25 MHz range using a Levenberg-Marquardt regression technique. The model was defined by the UCA size distribution and concentration, and therefore concentration estimates were extracted directly from the fit. Calculation of the BSC was accomplished using planar reference measurements from the back wall of a Plexiglas(®) chamber and an average of 500 snapshots of ultrasonic backscatter from UCAs flowing through the chamber. In order to verify the ultrasonically derived UCA concentration estimates, a sample of the UCAs was extracted from the flow path and the concentration was estimated with a hemacytometer. UCA concentrations of 1, 2, and 5 times the dose recommended by the manufacturer were used in experiments. All BSC-based estimates were within one standard deviation of hemacytometer based estimates for peak rarefactional pressures of 100-400 kPa.
Authors:
Scott M Leithem; Roberto J Lavarello; William D O'Brien; Michael L Oelze
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  131     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-06-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2295-305     Citation Subset:  IM    
Copyright Information:
© 2012 Acoustical Society of America
Affiliation:
Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, 405 North Mathews, Urbana, Illinois 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Contrast Media / chemistry*
Glass
Models, Theoretical
Particle Size
Phantoms, Imaging
Scattering, Radiation
Ultrasonics*
Grant Support
ID/Acronym/Agency:
R37 EB002641/EB/NIBIB NIH HHS; R37 EB002641/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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