Document Detail

Estimating the neurocognitive effects of an early intervention program for children with prenatal alcohol exposure.
MedLine Citation:
PMID:  19934465     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Animal studies suggest that early intervention in pups exposed heavily to ethanol in utero can mitigate their neurocognitive damage. No human studies on this promising mechanism exists. METHODS: Breaking the Cycle is an early intervention program for drug-and alcohol addicted mothers and their young children. We compared BSID-III scores between infants heavily exposed to ethanol and a group exposed only to drugs of abuse, mainly cocaine. Both groups benefited from all aspects of our early intervention program. RESULTS: The two groups did not differ in any aspect of the BSID-III. These data are in contradistinction to the damage seen in heavily ethanol- exposed infants not benefiting from early intervention. CONCLUSIONS: This pilot suggests that early intervention may mitigate some of the well described damages caused by heavy in utero alcohol exposure.
Parvaneh Yazdani; Mary Motz; Gideon Koren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-19
Journal Detail:
Title:  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique     Volume:  16     ISSN:  1710-6222     ISO Abbreviation:  Can J Clin Pharmacol     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804162     Medline TA:  Can J Clin Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e453-9     Citation Subset:  IM    
ivision of Clinical Pharmacology &Toxicology, Hospital for Sick Children andUniversity of Toronto, Toronto.
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MeSH Terms
Alcoholism / complications*
Child Development / drug effects
Cocaine-Related Disorders / complications
Cognition / drug effects
Developmental Disabilities / diagnosis*,  etiology,  psychology
Early Intervention (Education)*
Fetal Alcohol Syndrome / diagnosis,  etiology,  psychology
Infant, Newborn
Language Development Disorders / chemically induced,  diagnosis,  psychology
Maternal-Fetal Exchange
Motor Activity / drug effects
Pilot Projects
Pregnancy Complications*
Prenatal Exposure Delayed Effects / diagnosis*
Substance-Related Disorders / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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