| Estimating missing heritability for disease from genome-wide association studies. | |
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MedLine Citation:
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PMID: 21376301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantitative traits that estimates the variation accounted for when fitting all SNPs simultaneously. Here we develop this method further for case-control studies. We use a linear mixed model for analysis of binary traits and transform the estimates to a liability scale by adjusting both for scale and for ascertainment of the case samples. We show by theory and simulation that the method is unbiased. We apply the method to data from the Wellcome Trust Case Control Consortium and show that a substantial proportion of variation in liability for Crohn disease, bipolar disorder, and type I diabetes is tagged by common SNPs. |
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Authors:
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Sang Hong Lee; Naomi R Wray; Michael E Goddard; Peter M Visscher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-03 |
Journal Detail:
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Title: American journal of human genetics Volume: 88 ISSN: 1537-6605 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-05-16 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: United States |
Other Details:
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Languages: eng Pagination: 294-305 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bipolar Disorder
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genetics Case-Control Studies Computer Simulation Crohn Disease / genetics Diabetes Mellitus, Type 1 / genetics Disease / genetics* Genetic Variation Genome-Wide Association Study / methods* Humans Inheritance Patterns / genetics* Models, Genetic Polymorphism, Single Nucleotide / genetics Quality Control |
| Grant Support | |
ID/Acronym/Agency:
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076113//Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Am J Hum Genet. 2011 Jul 15;89(1):191-3; author reply 193-5
[PMID:
21763486
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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