Document Detail


Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance.
MedLine Citation:
PMID:  20214666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.
Authors:
Henrik Gutte; Michael L Møller; Andreas K Pfeifer; Jørgen Thorup; Line Borgwardt; Lise Borgwardt; Ulrik S Kristoffersen; Andreas Kjaer
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-02-27
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark. henrik.gutte@rh.regionh.dk
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MeSH Terms
Descriptor/Qualifier:
Child
Child, Preschool
Chromium Radioisotopes / diagnostic use,  pharmacokinetics
Edetic Acid / diagnostic use,  pharmacokinetics*
Female
Glomerular Filtration Rate*
Humans
Infant
Infant, Newborn
Kidney / metabolism*,  radionuclide imaging
Kidney Diseases / metabolism*,  radionuclide imaging*
Male
Metabolic Clearance Rate
Radioisotope Renography / methods*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Pentetate / diagnostic use,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Radiopharmaceuticals; 60-00-4/Edetic Acid; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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