Document Detail

Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance.
MedLine Citation:
PMID:  20214666     Owner:  NLM     Status:  MEDLINE    
Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.
Henrik Gutte; Michael L Møller; Andreas K Pfeifer; Jørgen Thorup; Line Borgwardt; Lise Borgwardt; Ulrik S Kristoffersen; Andreas Kjaer
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-02-27
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark.
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MeSH Terms
Child, Preschool
Chromium Radioisotopes / diagnostic use,  pharmacokinetics
Edetic Acid / diagnostic use,  pharmacokinetics*
Glomerular Filtration Rate*
Infant, Newborn
Kidney / metabolism*,  radionuclide imaging
Kidney Diseases / metabolism*,  radionuclide imaging*
Metabolic Clearance Rate
Radioisotope Renography / methods*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Pentetate / diagnostic use,  pharmacokinetics*
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Radiopharmaceuticals; 60-00-4/Edetic Acid; 65454-61-7/Technetium Tc 99m Pentetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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