| Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance. | |
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MedLine Citation:
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PMID: 20214666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow. |
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Authors:
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Henrik Gutte; Michael L Møller; Andreas K Pfeifer; Jørgen Thorup; Line Borgwardt; Lise Borgwardt; Ulrik S Kristoffersen; Andreas Kjaer |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2010-02-27 |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 30 ISSN: 1475-097X ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark. henrik.gutte@rh.regionh.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Chromium Radioisotopes / diagnostic use, pharmacokinetics Edetic Acid / diagnostic use, pharmacokinetics* Female Glomerular Filtration Rate* Humans Infant Infant, Newborn Kidney / metabolism*, radionuclide imaging Kidney Diseases / metabolism*, radionuclide imaging* Male Metabolic Clearance Rate Radioisotope Renography / methods* Radiopharmaceuticals / diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity Technetium Tc 99m Pentetate / diagnostic use, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Chromium Radioisotopes; 0/Radiopharmaceuticals; 60-00-4/Edetic Acid; 65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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