Document Detail

Estimating FVC from FEV2 and FEV3: assessment of a surrogate spirometric parameter.
MedLine Citation:
PMID:  16162718     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the context that accurate measurement of FVC is important in diagnosing airflow obstruction and in assessing restriction, strategies to achieve reliable and accurate FVC measurement have drawn much attention. OBJECTIVES: Because the rate of achieving end-of-test criteria during spirometry has been shown to be low, with resultant under-recording of the FVC, the current study proposes a regression equation for estimating FVC from measured values of the forced expiratory volume in 2 s (FEV2) and forced expiratory volume in 3 s (FEV3). METHODS: The predictive equation for the estimated FVC from volume measurements within the first 3 s of exhalation (estimated FVC3) was generated based on 330 consecutive acceptable spirograms performed in the Cleveland Clinic Foundation Pulmonary Function Laboratory. The equation was applied to an independent validation set comprised of spirometry measurements on 370 different consecutive patients. RESULTS: In the validation spirometry sample, in which the prevalence of obstruction was 34% (based on values of the measured FEV1/FVC compared to National Health and Nutrition Examination Survey III values), the sensitivity, specificity, and positive and negative predictive values of FEV1/estimated FVC3 for obstruction were 93.8%, 89.1%, 81.2%, and 96.9%, respectively. The misclassification rate was 9.2%. In the same cohort, the mean difference (+/- SD) between estimated FVC3 and measured FVC was 24.7 +/- 237 mL. CONCLUSIONS: Given that FVC is frequently under-recorded, with resultant overestimation of FEV1/FVC and underdiagnosis of airflow obstruction, we believe that estimating FVC from FEV2 and FEV3 can offer practical diagnostic advantages.
Octavian C Ioachimescu; Saiprakash B Venkateshiah; Mani S Kavuru; Kevin McCarthy; James K Stoller
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Chest     Volume:  128     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-15     Completed Date:  2005-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1274-81     Citation Subset:  AIM; IM    
Department of Pulmonary, Allergy, and Critical Care Medicine, The Cleveland Clinic Foundation, 9500 Euclid Ave A90, Cleveland, OH 44195, USA.
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MeSH Terms
Airway Obstruction / diagnosis*,  etiology
Cohort Studies
Forced Expiratory Volume*
Lung Diseases / complications,  diagnosis*
Middle Aged
Models, Biological
Predictive Value of Tests
Vital Capacity*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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