Document Detail

Estimating the burden of total knee replacement in the United States.
MedLine Citation:
PMID:  23344005     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the last decade, the number of total knee replacements performed annually in the United States has doubled, with disproportionate increases among younger adults. While total knee replacement is a highly effective treatment for end-stage knee osteoarthritis, total knee replacement recipients can experience persistent pain and severe complications. We are aware of no current estimates of the prevalence of total knee replacement among adults in the U.S.
METHODS: We used the Osteoarthritis Policy Model, a validated computer simulation model of knee osteoarthritis, and data on annual total knee replacement utilization to estimate the prevalence of primary and revision total knee replacement among adults fifty years of age or older in the U.S. We combined these prevalence estimates with U.S. Census data to estimate the number of adults in the U.S. currently living with total knee replacement. The annual incidence of total knee replacement was derived from two longitudinal knee osteoarthritis cohorts and ranged from 1.6% to 11.9% in males and from 2.0% to 10.9% in females.
RESULTS: We estimated that 4.0 million (95% confidence interval [CI]: 3.6 million to 4.4 million) adults in the U.S. currently live with a total knee replacement, representing 4.2% (95% CI: 3.7% to 4.6%) of the population fifty years of age or older. The prevalence was higher among females (4.8%) than among males (3.4%) and increased with age. The lifetime risk of primary total knee replacement from the age of twenty-five years was 7.0% (95% CI: 6.1% to 7.8%) for males and 9.5% (95% CI: 8.5% to 10.5%) for females. Over half of adults in the U.S. diagnosed with knee osteoarthritis will undergo a total knee replacement.
CONCLUSIONS: Among older adults in the U.S., total knee replacement is considerably more prevalent than rheumatoid arthritis and nearly as prevalent as congestive heart failure. Nearly 1.5 million of those with a primary total knee replacement are fifty to sixty-nine years old, indicating that a large population is at risk for costly revision surgery as well as possible long-term complications of total knee replacement.
Alexander M Weinstein; Benjamin N Rome; William M Reichmann; Jamie E Collins; Sara A Burbine; Thomas S Thornhill; John Wright; Jeffrey N Katz; Elena Losina
Related Documents :
19756205 - Major league baseball players' life expectancies*
1038615 - Perception of life change events by the elderly.
20298265 - Fiji's worst natural disaster: the 1931 hurricane and flood.
10807025 - The relationship of impending death and age category to treatment intensity in the elde...
24755635 - Effects of age, adipose percent, and reproduction on pcb concentrations and profiles in...
9988235 - Integrated approach to prediction of cervical intra-epithelial neoplasia status through...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  95     ISSN:  1535-1386     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-04-22     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Distribution
Aged, 80 and over
Arthroplasty, Replacement, Knee / utilization*
Computer Simulation
Cost of Illness
Disease Progression
Longitudinal Studies
Middle Aged
Models, Biological
Osteoarthritis, Knee / epidemiology,  surgery*
Reoperation / utilization
Sex Distribution
United States / epidemiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Small RNA-Mediated Epigenetic Myostatin Silencing.
Next Document:  Verrucous Cutaneous Sarcoidosis: Case Report and Review of This Unusual Variant of Cutaneous Sarcoid...