| Estimates of systolic and diastolic myocardial blood flow by dynamic contrast-enhanced MRI. | |
| | |
MedLine Citation:
|
PMID: 20928890 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Myocardial blood flow varies during the cardiac cycle in response to pulsatile changes in epicardial circulation and cyclical variation in myocardial tension. First-pass assessment of myocardial perfusion by dynamic contrast-enhanced MRI is one of the most challenging applications of MRI because of the spatial and temporal constraints imposed by the cardiac physiology and the nature of dynamic contrast-enhanced MRI signal collection. Here, we describe a dynamic contrast-enhanced MRI method for simultaneous assessment of systolic and diastolic myocardial blood flow. The feasibility of this method was demonstrated in a study of 17 healthy volunteers at rest and under adenosine-induced vasodilatory stress. We found that myocardial blood flow was independent of the cardiac phase at rest. However, under adenosine-induced hyperemia, myocardial blood flow and myocardial perfusion reserve were significantly higher in diastole than in systole. Furthermore, the transmural distribution of myocardial blood flow and myocardial perfusion reserve was cardiac phase dependent, with a reversal of the typical subendocardial to subepicardial myocardial blood flow gradient in systole, but not diastole, under stress. The observed difference between systolic and diastolic myocardial blood flow must be taken into account when assessing myocardial blood flow using dynamic contrast-enhanced MRI. Furthermore, targeted assessment of systolic or diastolic perfusion using dynamic contrast-enhanced MRI may provide novel insights into the pathophysiology of ischemic and microvascular heart disease. |
| | |
Authors:
|
Aleksandra Radjenovic; John D Biglands; Abdulghani Larghat; John P Ridgway; Stephen G Ball; John P Greenwood; Michael Jerosch-Herold; Sven Plein |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-06 |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1696-703 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
|
School of Medicine, University of Leeds, Leeds, United Kingdom. a.radjenovic@leeds.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
078288//Wellcome Trust; RG/05/004//British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of blood inflow and B(1)-field inhomogeneity on measurement of the arterial input functio...
Next Document: First-pass contrast-enhanced myocardial perfusion MRI in mice on a 3-T clinical MR scanner.