Document Detail


Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand.
MedLine Citation:
PMID:  2733058     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD; commonly known as dioxin) in serum has been measured in 36 Air Force Vietnam veterans of Operation Ranch Hand, which was the operation that aerially sprayed the herbicide Agent Orange in Vietnam. From serum specimens taken in 1982 and 1987, the median half-life of 2,3,7,8-TCDD in these Ranch Hand veterans was found to be 7.1 yr (95% confidence interval about the median of 5.8-9.6 yr). These veterans reported no civilian exposure to dioxin or herbicides. Concentrations of 2,3,7,8-TCDD in the 1982 serum specimens from these veterans ranged from 16.9 to 423 parts per trillion on a lipid weight basis. The half-life estimates were not associated with the concentration of 2,3,7,8-TCDD in the 1982 serum specimens. This half-life of 7.1 yr is much longer than the half-life of 2,3,7,8-TCDD reported in animals but is consistent with recent evidence from other human exposures to 2,3,7,8-TCDD.
Authors:
J L Pirkle; W H Wolfe; D G Patterson; L L Needham; J E Michalek; J C Miner; M R Peterson; D L Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  27     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-24     Completed Date:  1989-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Affiliation:
Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Atlanta, Georgia 30333.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Dioxins / blood*
Half-Life
Humans
Male
Middle Aged
Military Personnel
Pesticide Residues / blood*
Tetrachlorodibenzodioxin / blood*
Time Factors
Veterans*
Vietnam
Chemical
Reg. No./Substance:
0/Dioxins; 0/Pesticide Residues; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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