Document Detail


Estimated risk of West Nile virus transmission through blood transfusion during an epidemic in Queens, New York City.
MedLine Citation:
PMID:  12385413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human West Nile virus (WNV) infection has been documented in the eastern United States since its discovery there in 1999. Epidemics of WNV encephalitis and meningitis raise concern that transmission of WNV may occur through voluntary blood donations. STUDY DESIGN AND METHODS: Case onset dates from the 1999 Queens, NY, epidemic of WNV encephalitis and meningitis, and historic data on viremia in humans are used to estimate the number of cases that were viremic throughout the epidemic. Estimates of the inapparent-to-apparent WNV infection ratio, the proportion of asymptomatic infections reported in a seroepidemiologic survey coincident with the epidemic, and the population size are used to infer the WNV transfusion-transmission risk. Statistical resampling methods are used. RESULTS: The maximum and mean risk of WNV transmission (/10,000) from donors in Queens were estimated as 2.7 (95% CI, 0.9-5.6) and 1.8 (95% CI, 1.4-2.2), respectively. The risk peaked in late August, with very low risk before August and after September. CONCLUSION: Although most WNV-infected individuals have subclinical infections, these data suggest a low prevalence of viremia throughout the Queens epidemic and subsequent low risk of transmission of WNV by blood transfusion.
Authors:
Brad J Biggerstaff; Lyle R Petersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  42     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-18     Completed Date:  2002-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1019-26     Citation Subset:  IM    
Affiliation:
Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, CDC, Fort Collins, CO 80522-2087, USA. bbiggerstaff@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Blood Donors
Blood Transfusion / adverse effects*
Disease Outbreaks*
Humans
New York City / epidemiology
Risk Assessment
Viremia / epidemiology
West Nile Fever / epidemiology*,  transmission*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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