Document Detail

Estimated personal soot exposure is associated with acute myocardial infarction onset in a case-crossover study.
MedLine Citation:
PMID:  21414471     Owner:  NLM     Status:  MEDLINE    
The current study investigates the association of estimated personal exposure to traffic-related air pollution and acute myocardial infarction (AMI). Cases of AMI were interviewed in the Augsburg KORA Myocardial Infarction Registry from February 1999 through December 2003, and 960 AMI survivors were included in the analyses. The time-varying component of daily personal soot exposure (the temporally variable contribution due to the daily area level of exposure and daily personal activities) was estimated using a linear combination of estimated mean ambient soot concentration, time spent outdoors, and time spent in traffic. The association of soot exposure with AMI onset was estimated in a case-crossover analysis controlling for temperature and day of the week using conditional logistic regression analyses. Estimated personal soot exposure was associated with AMI (relative risk, 1.30 per 1.1 m(-1) × 10(-5) [95% confidence interval, 1.09-1.55]). Estimated ambient soot and measured ambient PM(2.5) particulate matter 2.5 µm and smaller in aerodynamic diameter were not significantly associated with AMI onset. Our results suggest that an increase in risk of AMI in association with personal soot exposure may be in great part due to the contribution of personal soot from individual times spent in traffic and individual times spent outdoors. As a consequence, estimates calculated based on measurements at urban background stations may be underestimations. Health effects of traffic-related air pollution may need to be updated, taking into account individual time spent in traffic and outdoors, to adequately protect the public.
Stephanie von Klot; Josef Cyrys; Gerard Hoek; Brigitte Kühnel; Mike Pitz; Ulrike Kuhn; Bernhard Kuch; Christa Meisinger; Allmut Hörmann; H-Erich Wichmann; Annette Peters
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  53     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-05-16     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
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MeSH Terms
Cross-Over Studies
Environmental Monitoring
Inhalation Exposure
Life Style
Logistic Models
Middle Aged
Myocardial Infarction / etiology*
Odds Ratio
Particle Size
Public Health
Risk Assessment
Risk Factors
Soot / adverse effects*
Time Factors
Urban Health*
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Soot; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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