Document Detail


Estimated Contribution of Hemoglobin and Myoglobin to Near Infrared Spectroscopy.
MedLine Citation:
PMID:  23357615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We calculated the light-absorbing-potential (LAP) of hemoglobin (Hb) and myoglobin (Mb) in mammalian skeletal muscle at rest based on analysis of published chemical and morphometric data (Part 1), interpreted changes in total [Hb+Mb] from NIRS during exercise (Part 2), and estimated the potential contribution of Hb and Mb to changes in NIRS from rest to exercise (Part 3). Part 1: [Hb] in skeletal muscle was estimated from microvascular volume, systemic blood [Hb], and microvascular hematocrit and saturation at rest and during exercise. Part 2: Changes in total [Hb]+[Mb] (as t[Hb+Mb]) during cycling or knee extension exercise were interpreted using the results of Part 1. Part 3: Using estimates of mean microvascular PO(2), Hb and Mb contribution at peak exercise was estimated. Across several species, [Mb] contributed ∼50-70% of the total LAP to NIRS at rest in skeletal muscle. With exercise, increases in t[Hb+Mb] of up to 30% could be entirely explained by the predicted increase in microvascular hematocrit with exercise. Finally, Mb was estimated to contribute ∼70% of the changes in NIRS from rest to peak exercise.
Authors:
Michelle L Davis; Thomas J Barstow
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-25
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
Human Exercise Physiology Research Laboratory, Department of Kinesiology, 1A Natatorium, Kansas State University, Manhattan, KS 66506-0302.
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