Document Detail

Esthesioneuroblastoma in the pediatric age-group: the role of chemotherapy and autologous bone marrow transplantation.
MedLine Citation:
PMID:  8884406     Owner:  NLM     Status:  MEDLINE    
Esthesioneuroblastoma, a malignant neoplasm arising from olfactory epithelium, is unusual in the pediatric age-group. Management has traditionally involved surgery and radiotherapy, alone or in combination, with chemotherapy reserved for recurrent or high grade disease. We report a single institution experience utilizing chemotherapy and radiotherapy as the initial treatment and successful control of the primary tumor in two patients. In one patient, neck dissection and high dose chemotherapy combined with autologous bone marrow transplantation were used as successful salvage therapy of neck metastasis. Both patients are alive and disease free with a mean follow-up of 56 months. These results support the role of chemotherapy in the treatment of esthesioneuroblastoma and suggest that chemotherapy be used as part of the initial combined modality treatment plan.
Q A Nguyen; J G Villablanca; S E Siegel; D M Crockett
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  37     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-29     Completed Date:  1997-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Los Angeles County-University of Southern California Medical Center 90033, USA.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Bone Marrow Transplantation*
Esthesioneuroblastoma, Olfactory / drug therapy*,  pathology
Nasopharyngeal Neoplasms / drug therapy*,  pathology
Nasopharynx / pathology
Tomography, X-Ray Computed
Transplantation, Autologous*
Reg. No./Substance:
0/Antineoplastic Agents

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