Document Detail

Esterified estrogens combined with methyltestosterone raise intraocular pressure in postmenopausal women.
MedLine Citation:
PMID:  16935599     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effect of esterified estrogens combined with methyltestosterone (EECM) (Estratest, Solvay, Pharmaceuticals, Inc, Baudette, Minnesota, USA) on intraocular pressure (IOP) in postmenopausal women. DESIGN: Observational case series. METHODS: The IOP of 13 consecutive postmenopausal women with dry eye syndrome were recorded before and during EECM therapy (1.25 mg of esterified estrogens and 2.5 mg of methyltestosterone for several months). RESULTS: The mean IOP increased from a baseline of 15.0 mm Hg before treatment to 18.2 mm Hg on EECM therapy (P < .0001) after a median duration of 11.3 months (range, 0.9 to 24 months). The increase in IOP was statistically significant at the 0.05 level of significance within three months and continued over 12 months. Two patients whose pressures increased (>4 mm Hg) returned to baseline levels after EECM was discontinued. CONCLUSIONS: Esterified estrogens combined with methyltestosterone produce a clinically significant increase in IOP in postmenopausal women with dry eye syndrome.
Rahul N Khurana; Laurie D LaBree; Garrett Scott; Ronald E Smith; Samuel C Yiu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  142     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-09-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-5     Citation Subset:  AIM; IM    
Ocular Surface Center, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
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MeSH Terms
Aged, 80 and over
Dry Eye Syndromes / complications
Estrogen Replacement Therapy
Estrogens / adverse effects*
Estrogens, Esterified (USP) / adverse effects
Intraocular Pressure / drug effects*
Methyltestosterone / adverse effects*
Middle Aged
Retrospective Studies
Tonometry, Ocular
Grant Support
Reg. No./Substance:
0/Estratest-HS; 0/Estrogens; 0/Estrogens, Esterified (USP); 58-18-4/Methyltestosterone

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