| Establishment of self-sequential longitudinal reference intervals of maternal thyroid function during pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20810761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective of this study is to establish self-sequential longitudinal reference intervals of thyroid function in normal pregnant women. According to the selection criteria, 301 cases were taken as the normal pregnant population to establish a normal reference range. Meanwhile, 150 healthy women were selected as the normal non-pregnant control group. To establish their own self-sequential longitudinal reference intervals, we collected samples five times in every case throughout the gestation (including first trimester, second trimester, third trimester, prenatal and postpartum), and detected the levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibodies (TPO-Ab), and then established the self-sequential longitudinal reference intervals. The levels of TSH, FT4 and TPO-Ab were quantified by electrochemistry immunoassay (ECL) and statistically analyzed using SPSS 13.0 software. Serum TSH of normal pregnant women was at a low level in the first trimester (P < 0.05) and began to rise continuously. Not until prenatal phase was it restored to the non-pregnant state (P > 0.05). During pregnancy, serum FT4 of normal pregnant women were consistently lower than non-pregnant levels (P < 0.05) and kept at low levels. Serum TPO-Ab increased significantly in the third trimester and prenatal phase (P < 0.05). Of normal pregnant women, 6.5% were TPO-Ab positive. In conclusion, the reference intervals in our case will reflect the changes of thyroid function in pregnant women more realistically, resulting in a more accurate value for clinical diagnosis and therapy. |
| | |
Authors:
|
Bin Yu; Qiu-Wei Wang; Rui-Ping Huang; Fang Cao; Zi-Qiang Zhu; Da-Cheng Sun; Hong Zhou; Yi-Ming Zhang |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-01 |
Journal Detail:
|
Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2010-10-28 Revised Date: 2011-03-11 |
Medline Journal Info:
|
Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
|
Languages: eng Pagination: 1212-5 Citation Subset: IM |
Affiliation:
|
Changzhou Women and Children Health Hospital affiliated to Nanjing Medical University, No. 26 Bo Ai Road, Changzhou 213003, Jiangsu Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Autoantibodies / blood Case-Control Studies Female Humans Iodide Peroxidase / immunology Longitudinal Studies Postpartum Period / blood, immunology Pregnancy / blood, immunology, physiology* Pregnancy Trimesters / blood, immunology Reference Values Thyroid Gland / immunology, physiology* Thyrotropin / blood Thyroxine / blood Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in...
Next Document: Chronic shedders as reservoir for nosocomial transmission of norovirus.