Document Detail


Establishment of predictive variables associated with testicular sperm retrieval in men with non-obstructive azoospermia.
MedLine Citation:
PMID:  10221234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although testicular biopsy for sperm extraction is a procedure with a potential for complications, sperm retrieval is successful in 30-70% of patients with non-obstructive azoospermia. In order to predict the probability of retrieving at least one testicular spermatozoon we conducted a prospective study of a set of variables in 40 patients with non-obstructive azoospermia. Using the receiver operating characteristic curves, we determined the probability estimates of testicular volume, plasma follicle stimulating hormone (FSH) concentration, Johnsen score and visualization of testicular spermatids in discriminating between patients with successful and failed testicular sperm extraction. Visualization of testicular spermatids provided the best estimate of success of testicular sperm extraction. Of the factors studied using logistic-regression analysis (age, maternal and paternal age at birth, body mass index, luteinizing hormone, testosterone, FSH, testicular volume, the presence of testicular spermatids and Johnsen score), only the presence of spermatids and Johnsen score were independent variables able to predict the success of testicular sperm extraction. The visualization of the presence of spermatids gave a correct prediction of 77% and Johnsen score of 71%. The diagnostic model derived from these independent predictors when validated in 40 patients using the Jackknife technique gave a correct overall prediction of 87%. The probability of successful testicular sperm extraction in patients with non-obstructive azoospermia could be objectively predicted on the basis of simple histopathological criteria represented by the visualization of testicular spermatids and Johnsen score.
Authors:
U I Ezeh; N A Taub; H D Moore; I D Cooke
Related Documents :
19819894 - Is meaningful reporting of national ivf outcome data possible?
22973674 - Evaluation of serotype-specific immunity to streptococcus pneumoniae in pregnant women ...
16324074 - Artificial insemination of gilts with 1.5 billion sperms stored in different periods as...
22384654 - Chorioretinitis in infants.
11699024 - The effectiveness of a thermal mattress in stabilizing and maintaining body temperature...
11004234 - Evolution in the hypervariable region of hepatitis c virus in infants after vertical tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  14     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1005-12     Citation Subset:  IM    
Affiliation:
University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biopsy
Cell Separation*
Diagnostic Techniques and Procedures
Humans
Male
Oligospermia / pathology*,  therapy
Predictive Value of Tests
Regression Analysis
Spermatozoa / pathology*
Testis / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of image sampling frequency on established and smoothing-independent kinematic values of capa...
Next Document:  A novel approach to sperm cryopreservation.