Document Detail

Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary.
MedLine Citation:
PMID:  17434504     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess directly the dynamics of the formation of the ovarian reserve in the normal human ovary by evaluating the total number of follicles in developing ovaries when folliculogenesis occurs. DESIGN: Histomorphometry-based follicle counts in complete serial tissue sections. SETTING: Functional Anatomy Research Center, University of Milano. PATIENT(S): Thirteen fetuses, neonates, and one 8-month-old infant. INTERVENTION(S): Fifteen ovaries were completely cut, obtaining serial sections. Ovarian volume, volume fractions, density and total number of follicles per ovary were calculated using quantitative morphometric methods. MAIN OUTCOME MEASURE(S): Age-related dynamics of the establishment of ovarian reserve in human developing ovary at the end of the organogenesis. RESULT(S): The ovarian reserve (100,000 follicles at 15 weeks of postconceptional age) increased progressively to 680,000 follicles at 34 weeks. At 8 months of postnatal age the pool was still about 680,000 primordial follicles. CONCLUSION(S): The consistence of the primordial follicle pool during organogenesis shows an exponential increase until month 8 of prenatal life and it is subsequently maintained without modifications at least until month 8 of postnatal life.
Antonino Forabosco; Chiarella Sforza
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Publication Detail:
Type:  Journal Article     Date:  2007-04-16
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-09-25     Revised Date:  2008-04-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-83     Citation Subset:  IM    
Medical Genetics Unit, Dipartimento Materno Infantile, Facoltà di Medicina e Chirurgia, Università degli Studi di Modena e Reggio Emilia, Modena, Italy. <>
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MeSH Terms
Congenital Abnormalities* / embryology,  genetics,  mortality
Fetal Death*
Fetal Development
Fetus / physiology*
Infant, Newborn
Ovary / anatomy & histology*,  cytology*,  growth & development,  physiology*
Comment In:
Fertil Steril. 2008 Apr;89(4):1028-9; author reply 1029   [PMID:  18325502 ]

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