Document Detail

Establishment of the need for oestrogen during implantation in non-human primates.
MedLine Citation:
PMID:  17509195     Owner:  NLM     Status:  MEDLINE    
Deprivation of oestrogen during post-ovulatory mated cycles in proven fertile female bonnet monkeys by tamoxifen, aromatase inhibitor or oestrogen antiserum resulted in inhibition of pregnancy establishment in all three groups of animals. However, more than 85% of the animals became pregnant within three exposures to proven fertile males in the control group. These results suggest the requirement for oestrogen in pregnancy establishment in primates. Based on this conclusion, it is suggested that use of a suitable and potent anti-oestrogenic compound can be exploited as an alternative approach to contraception.
A Jagannadha Rao; S G Ramachandra; V Ramesh; H N Krishnamurthy; N Ravindranath; N R Moudgal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  14     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  563-71     Citation Subset:  IM    
Indian Institute of Science, Bangalore 560 012, India.
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MeSH Terms
Antibodies / immunology
Aromatase Inhibitors / pharmacology
Embryo Implantation / physiology*
Estradiol / blood
Estrogen Antagonists / pharmacology
Estrogens / immunology,  physiology*
Fadrozole / pharmacology
Macaca radiata
Menstrual Cycle / blood,  physiology
Pregnancy, Animal / drug effects,  physiology*
Progesterone / blood
Tamoxifen / pharmacology
Reg. No./Substance:
0/Antibodies; 0/Aromatase Inhibitors; 0/Estrogen Antagonists; 0/Estrogens; 102676-47-1/Fadrozole; 10540-29-1/Tamoxifen; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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