| Establishment of the need for oestrogen during implantation in non-human primates. | |
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MedLine Citation:
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PMID: 17509195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deprivation of oestrogen during post-ovulatory mated cycles in proven fertile female bonnet monkeys by tamoxifen, aromatase inhibitor or oestrogen antiserum resulted in inhibition of pregnancy establishment in all three groups of animals. However, more than 85% of the animals became pregnant within three exposures to proven fertile males in the control group. These results suggest the requirement for oestrogen in pregnancy establishment in primates. Based on this conclusion, it is suggested that use of a suitable and potent anti-oestrogenic compound can be exploited as an alternative approach to contraception. |
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Authors:
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A Jagannadha Rao; S G Ramachandra; V Ramesh; H N Krishnamurthy; N Ravindranath; N R Moudgal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 14 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-18 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 563-71 Citation Subset: IM |
Affiliation:
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Indian Institute of Science, Bangalore 560 012, India. ajrao@biochem.iisc.ernet.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / immunology Aromatase Inhibitors / pharmacology Embryo Implantation / physiology* Estradiol / blood Estrogen Antagonists / pharmacology Estrogens / immunology, physiology* Fadrozole / pharmacology Female Macaca radiata Menstrual Cycle / blood, physiology Pregnancy Pregnancy, Animal / drug effects, physiology* Progesterone / blood Tamoxifen / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Aromatase Inhibitors; 0/Estrogen Antagonists; 0/Estrogens; 102676-47-1/Fadrozole; 10540-29-1/Tamoxifen; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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