Document Detail

Establishment of a model of penicillin-resistant Streptococcus pneumoniae pneumonia in healthy CBA/J mice.
MedLine Citation:
PMID:  8918945     Owner:  NLM     Status:  MEDLINE    
Examination of strain differences in the susceptibility of mice to experimental respiratory tract infection with penicillin-resistant Streptococcus pneumoniae TUM19 revealed that a fatal infection model could be induced in immunocompetent CBA/J mice, but not in C3H/HeN, C57BL/6 or ICR mice. After intranasal instillation of c. 10(6) cfu of S. pneumoniae, the bacterial counts in the lungs of CBA/J mice increased from 10(5) to 10(7) cfu after 3-5 days, and gradually increased thereafter. The challenge organisms localised mainly in the lungs until 14 days after infection. Mice began to die c. 7 days after infection, and by 3 weeks most of the mice had died. Histopathologically, infiltration of neutrophils and lymphocytes around bronchi was observed from 1 day after infection, and fibrin deposition was seen in alveolar and bronchial spaces from 5 days. This model may be useful for investigating therapy of respiratory tract infection caused by penicillin-resistant S. pneumoniae because its pathological features resemble those observed in the human disease.
K Takashima; K Tateda; T Matsumoto; T Ito; Y Iizawa; M Nakao; K Yamaguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  45     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-12     Completed Date:  1996-12-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  319-22     Citation Subset:  IM    
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.
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MeSH Terms
Colony Count, Microbial
Disease Models, Animal*
Lung / microbiology,  pathology
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred CBA*
Mice, Inbred ICR
Penicillin Resistance*
Pneumonia, Bacterial / microbiology*
Streptococcal Infections / microbiology*
Streptococcus pneumoniae / drug effects*,  growth & development

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