Document Detail


Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.
MedLine Citation:
PMID:  1260746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A human carcinoembryonic antigen-producing colon carcinoma cell line has been established. The cells form acinar structures and signet ring cells. The lumen of the acini presents microvilli and a glycocalyx. Neighboring cells show desmosomes and terminal bars. The cells present an aneuploid karyotype with a modal number of 49. No marker chromosomes are found, although a significant proportion of cells show an altered A2 chromosome and an extra B. Exponentially growing cultures produce 54 ng of carcinoembryonic antigen/10(6) cells. Kinetic parameters are as follows: doubling time, 37 hr; mitotic index, 0.8%; labeling index, 31%; generation time, 30 hr; G1 phase, 7 hr; S phase, 18 hr; G2 phase, 5 hr; growth fraction 90%. This cell line, designated line LoVo, represents an in vitro model for human colon carcinoma.
Authors:
B Drewinko; M M Romsdahl; L Y Yang; M J Ahearn; J M Trujillo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  36     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics,  immunology*,  pathology
Carcinoembryonic Antigen*
Cell Division
Cell Line
Cell Survival
Chromosome Aberrations
Chromosomes, Human, 1-3
Chromosomes, Human, 4-5
Chromosomes, Human, 6-12 and X
Colonic Neoplasms / genetics,  immunology*,  pathology
Humans
Chemical
Reg. No./Substance:
0/Carcinoembryonic Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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