Document Detail

Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.
MedLine Citation:
PMID:  1260746     Owner:  NLM     Status:  MEDLINE    
A human carcinoembryonic antigen-producing colon carcinoma cell line has been established. The cells form acinar structures and signet ring cells. The lumen of the acini presents microvilli and a glycocalyx. Neighboring cells show desmosomes and terminal bars. The cells present an aneuploid karyotype with a modal number of 49. No marker chromosomes are found, although a significant proportion of cells show an altered A2 chromosome and an extra B. Exponentially growing cultures produce 54 ng of carcinoembryonic antigen/10(6) cells. Kinetic parameters are as follows: doubling time, 37 hr; mitotic index, 0.8%; labeling index, 31%; generation time, 30 hr; G1 phase, 7 hr; S phase, 18 hr; G2 phase, 5 hr; growth fraction 90%. This cell line, designated line LoVo, represents an in vitro model for human colon carcinoma.
B Drewinko; M M Romsdahl; L Y Yang; M J Ahearn; J M Trujillo
Related Documents :
22184056 - Hyaluronan is required for cranial neural crest cells migration and craniofacial develo...
15667796 - Establishment of human embryonic stem cell line from gamete donors.
3010616 - Balanced terminal chromosome translocations develop in ebv-derived, but non-immortal ce...
7749146 - Influence of tumor derived fibroblasts and 1,25-dihydroxyvitamin d3 on growth of breast...
3860806 - Gestational changes in prostaglandin production by ovine fetal trophoblast cells.
12541286 - Quantifying cell scattering: the blob algorithm revisited.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  36     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-75     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / genetics,  immunology*,  pathology
Carcinoembryonic Antigen*
Cell Division
Cell Line
Cell Survival
Chromosome Aberrations
Chromosomes, Human, 1-3
Chromosomes, Human, 4-5
Chromosomes, Human, 6-12 and X
Colonic Neoplasms / genetics,  immunology*,  pathology
Reg. No./Substance:
0/Carcinoembryonic Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The concentration of 67Ga and 45Ca in the lactating mammary gland and its relevance to the tumor upt...
Next Document:  Potentiation of actinomycin D or adriamycin antitumor activity with DNA.