Document Detail


Establishment and development of intestinal microbiota in preterm neonates.
MedLine Citation:
PMID:  22126419     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Microbial colonization of the infant gut is essential for the development of the intestine and the immune system. The profile of intestinal microbiota in the full-term, vaginally delivered, breast-fed infant is considered as ideally healthy. However, in preterm infants this process is challenging, mainly due to organ immaturity, antibiotics use and hospital stay. To assist in a proper microbiota development in these infants a detailed knowledge of the colonization process, and the differences from that of full-term breast-fed infants, is needed. We assessed the establishment of the gut microbiota and its metabolic activity in preterm neonates (n=21) during the first three months of life and compared it with that of vaginally-delivered, exclusively breast-fed full-term infants (n=20) by using qualitative and quantitative culture-independent methods. Differences in the gut microbiota composition between both groups were observed. Preterm infants showed higher levels of facultative anaerobic microorganisms and reduced levels of strict anaerobes such as Bifidobacterium, Bacteroides and Atopobium. Short chain fatty acids concentrations were lower in preterm infants during the first days of life. Alterations occur in the process of microbiota establishment in preterm infants, indicating the need for intervention strategies to counteract them.
Authors:
Silvia Arboleya; Ana Binetti; Nuria Salazar; Nuria Fernández; Gonzalo Solís; Ana Hernández-Barranco; Abelardo Margolles; Clara G de Los Reyes-Gavilán; Miguel Gueimonde
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-29
Journal Detail:
Title:  FEMS microbiology ecology     Volume:  -     ISSN:  1574-6941     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901229     Medline TA:  FEMS Microbiol Ecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Department of Microbiology and Biochemistry, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Asturias, Spain.
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