| Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function. | |
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MedLine Citation:
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PMID: 18667022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uterine papillary serous carcinoma is an uncommon histologic subtype of endometrial cancer that behaves aggressively and has a poor prognosis. We successfully established a uterine papillary serous carcinoma cell line. The population-doubling time was approximately 16 h. Although loss of p53 function is considered critical for the molecular pathogenesis of uterine papillary serous carcinoma, p53 was not only mutated but functionally active in this cell line. This newly established cell line should be useful for investigating the characteristics of uterine papillary serous carcinoma. |
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Authors:
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Hisashi Hashimoto; Atsumi Kojima; Tamotsu Sudo; Noriyoshi Ohki; Satoshi Yamaguchi; Yoshiki Mikami; Masaharu Ito; Ryuichiro Nishimura |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human cell : official journal of Human Cell Research Society Volume: 21 ISSN: 0914-7470 ISO Abbreviation: Hum. Cell Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-31 Completed Date: 2008-10-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912329 Medline TA: Hum Cell Country: Japan |
Other Details:
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Languages: eng Pagination: 64-9 Citation Subset: IM |
Affiliation:
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Department of Translational Research, Ehime University School of Medicine, Toon, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Cell Division Cell Line, Tumor Cystadenocarcinoma, Papillary* / genetics, pathology Female Humans Karyotyping Mice Mice, Nude Mutation Neoplasm Transplantation Transplantation, Heterologous Tumor Suppressor Protein p53 / genetics*, physiology* Uterine Neoplasms* / genetics, pathology |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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