| Establishment and characterization of an Epstein-Barr virus nuclear antigen-negative hairy cell line. | |
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MedLine Citation:
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PMID: 2984056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous cell lines have been established from spleen cells of patients with confirmed hairy cell leukemia (HCL). One cell line, HCL-Z1, lacks Epstein-Barr virus nuclear antigen (EBNA), grows attached to the substratum and retains typical features of hairy cells as revealed by transmission and scanning electron microscopy. HCL-Z1 differs morphologically from the three other EBNA-positive lymphoblastoid cell lines obtained (HCL-Z2, HCL-Z3, HCL-Z4) as well as from normal spleen cells or lymphocytes. The three lymphoblastoid cell lines derived from HCL patients show similar surface features as a line from a myeloma patient. Therefore, not all cell lines derived from HCL patients may be considered as representative of the patients leukemia cells. |
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Authors:
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A B Lang; B F Odermatt; D R Gut; J R Rüttner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental cell biology Volume: 53 ISSN: 0304-3568 ISO Abbreviation: Exp. Cell Biol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-05-09 Completed Date: 1985-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701827 Medline TA: Exp Cell Biol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 61-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Viral
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analysis* Cell Line* Cell Nucleus / immunology Epstein-Barr Virus Nuclear Antigens Herpesvirus 4, Human / immunology Humans Leukemia, Hairy Cell / microbiology, pathology* Microscopy, Electron Spleen / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 0/Epstein-Barr Virus Nuclear Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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