Document Detail


Establishment and characterization of a CD5 positive, immunosuppressive human myeloma cell line.
MedLine Citation:
PMID:  1700238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A continuously growing, in vitro cell line with plasma cell characteristics has been established from the bone marrow of a patient with multiple myeloma. Surface marker characterization of the cells revealed a combination of markers normally associated with different developmental stages in the B cell lineage. The cell secretes immunoglobulin at a relatively low rate. The cell also expresses CD5 and secretes a factor which suppresses in vitro mitogen and antigen induced immunoglobulin synthesis by normal PBL.
Authors:
R J Scibienski; T G Paglieroni; M R MacKenzie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia     Volume:  4     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-26     Completed Date:  1990-12-26     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-80     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology and Immunology, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / analysis*
Antigens, CD5
Antigens, Differentiation / analysis*
Antigens, Differentiation, B-Lymphocyte / analysis
B-Lymphocytes / immunology,  metabolism
Glycoproteins / metabolism
Humans
Immune Tolerance*
Immunoglobulins / biosynthesis
Karyotyping
Multiple Myeloma / genetics,  immunology*,  metabolism
Tumor Cells, Cultured / immunology,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD5; 0/Antigens, Differentiation; 0/Antigens, Differentiation, B-Lymphocyte; 0/Glycoproteins; 0/Immunoglobulins; 0/serum immunosuppressive factor, human

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