| Establishment of Global Patterns of Planar Polarity during Growth of the Drosophila Wing Epithelium. | |
| | |
MedLine Citation:
|
PMID: 22727699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Epithelial tissues develop planar polarity that is reflected in the global alignment of hairs and cilia with respect to the tissue axes. The planar cell polarity (PCP) proteins form asymmetric and polarized domains across epithelial junctions that are aligned locally between cells and orient these external structures [1-3]. Although feedback mechanisms can polarize PCP proteins intracellularly and locally align polarity between cells, how global PCP patterns are specified is not understood. It has been proposed that the graded distribution of a biasing factor could guide long-range PCP [4, 5]. However, we recently identified epithelial morphogenesis as a mechanism that can reorganize global PCP patterns; in the Drosophila pupal wing, oriented cell divisions and rearrangements reorient PCP from a margin-oriented pattern to one that points distally [6]. Here, we use quantitative image analysis to study how PCP patterns first emerge in the wing. PCP appears during larval growth and is spatially oriented through the activities of three organizer regions that control disc growth and patterning. Flattening morphogen gradients emanating from these regions does not reduce intracellular polarity but distorts growth and alters specific features of the PCP pattern. Thus, PCP may be guided by morphogenesis rather than morphogen gradients. |
| | |
Authors:
|
Andreas Sagner; Matthias Merkel; Benoit Aigouy; Julia Gaebel; Marko Brankatschk; Frank Jülicher; Suzanne Eaton |
Related Documents
:
|
7772669 - Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polyme... 1493189 - Macrophage response to microtextured silicone. 6149119 - In situ 125i-labelling of endosome proteins with lactoperoxidase conjugates. 20831349 - Uv laser-ablated surface textures as potential regulator of cellular response. 21273599 - Atm/atr and smad3 pathways contribute to 3-indole-induced g₁ arrest in cancer cells a... 22583359 - Knockdown of bdnf suppressed invasion of hepg2 and hcclm3 cells, a mechanism associated... 6089389 - Morphological changes in pancreatic fragments prepared for transplantation by collagena... 1310669 - The histology and immunohistochemistry of small cell mesothelioma. 6763929 - Mandibular morphogenesis and craniofacial malformations. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-20 |
Journal Detail:
|
Title: Current biology : CB Volume: - ISSN: 1879-0445 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Propagation of Dachsous-Fat planar cell polarity.
Next Document: C. elegans Secreted Lipid-Binding Protein NRF-5 Mediates PS Appearance on Phagocytes for Cell Corps...