Document Detail

The establishment of the GENEQOL consortium to investigate the genetic disposition of patient-reported quality-of-life outcomes.
MedLine Citation:
PMID:  19456223     Owner:  NLM     Status:  MEDLINE    
To our knowledge, no comprehensive, interdisciplinary initiatives have been taken to examine the role of genetic variants on patient-reported quality-of-life outcomes. The overall objective of this paper is to describe the establishment of an international and interdisciplinary consortium, the GENEQOL Consortium, which intends to investigate the genetic disposition of patient-reported quality-of-life outcomes. We have identified five primary patient-reported quality-of-life outcomes as initial targets: negative psychological affect, positive psychological affect, self-rated physical health, pain, and fatigue. The first tangible objective of the GENEQOL Consortium is to develop a list of potential biological pathways, genes and genetic variants involved in these quality-of-life outcomes, by reviewing current genetic knowledge. The second objective is to design a research agenda to investigate and validate those genes and genetic variants of patient-reported quality-of-life outcomes, by creating large datasets. During its first meeting, the Consortium has discussed draft summary documents addressing these questions for each patient-reported quality-of-life outcome. A summary of the primary pathways and robust findings of the genetic variants involved is presented here. The research agenda outlines possible research objectives and approaches to examine these and new quality-of-life domains. Intriguing questions arising from this endeavor are discussed. Insight into the genetic versus environmental components of patient-reported quality-of-life outcomes will ultimately allow us to explore new pathways for improving patient care. If we can identify patients who are susceptible to poor quality of life, we will be able to better target specific clinical interventions to enhance their quality of life and treatment outcomes.
Mirjam A G Sprangers; Jeff A Sloan; Ruut Veenhoven; Charles S Cleeland; Michele Y Halyard; Amy P Abertnethy; Frank Baas; Andrea M Barsevick; Meike Bartels; Dorret I Boomsma; Cynthia Chauhan; Amylou C Dueck; Marlene H Frost; Per Hall; Pål Klepstad; Nicholas G Martin; Christine Miaskowski; Miriam Mosing; Benjamin Movsas; Cornelis J F Van Noorden; Donald L Patrick; Nancy L Pedersen; Mary E Ropka; Quiling Shi; Gen Shinozaki; Jasvinder A Singh; Ping Yang; Ailko H Zwinderman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  12     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-28     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  301-11     Citation Subset:  IM    
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MeSH Terms
Genetic Predisposition to Disease / psychology*
Genetic Variation
Health Status
Quality of Life / psychology*
Research Design
Grant Support
KL2 RR024151-01/RR/NCRR NIH HHS; U10 CA025224/CA/NCI NIH HHS; U10 CA025224-230006/CA/NCI NIH HHS

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