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Establishment of the Cumulative Margin of Exposure for a Group of Polychlorinated Biphenyl (PCB) Congeners Using an Improved Approach that Accounts for both Variability and Uncertainty.
MedLine Citation:
PMID:  23360570     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, the cumulative margin of exposure (MOE) was estimated for a group of polychlorinated biphenyls (PCBs) using reduction of hepatic vitamin A as a mode-of-action relevant toxicological endpoint. The MOE was defined as the ratio between a reference dose, derived using the benchmark dose (BMD) approach, and the estimated human dietary PCB exposure. A distribution for the cumulative MOE was established, taking into account inter- and intra-individual variability as well as uncertainty in data measurements. The cumulative MOE reflected mainly the MOE for PCB 126; other PCB congeners had little contribution to the cumulative exposure and MOE. The median of the 0.1(st) percentile for the cumulative MOE was about 20 for women; depending on the percentile, cumulative MOE was 2 - 4 times higher for men compared to women. Furthermore, a relative potency factor (RPF) based approach was compared to an RPF-free approach for estimating the cumulative MOE. The RPF-free approach more completely accounts for variability and uncertainty but is more data intensive than the RPF-based approach, which can be more easily implemented in practice and allows for a use of historical data on RPFs. Consideration of the discussed approaches may contribute to improving cumulative health risk assessments.
Authors:
Fereshteh Kalantari; Charlotte Bergkvist; Marika Berglund; Elena Fattore; Anders Glynn; Helen Håkansson; Salomon Sand
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-26
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  -     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Inc.
Affiliation:
Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, 17177, Stockholm, Sweden. Electronic address: Fereshteh.Kalantari@ki.se.
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