Document Detail


Establishing a national program for fetoscopic guided laser occlusion for twin-to-twin transfusion syndrome in Sweden.
MedLine Citation:
PMID:  22568938     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To describe the establishment of the fetoscopic guided laser occlusion (FLOC) technique for treatment of twin-twin transfusion syndrome (TTTS) and the initial results in a Swedish national center. Design. Retrospective, descriptive study. Setting. Tertiary level university hospital. Population. All referred and treated cases suffering significant TTTS. Methods. The present study includes all cases of FLOC for TTTS at the Center of Fetal Medicine at Karolinska University Hospital, Stockholm, Sweden from October 2001 until December 2009. Patients were referred from all over Sweden and a few from other Nordic countries. The patients were evaluated with ultrasound examination between gestational age of 18-26 weeks. Data from patients were extracted from our electronic medical record system and in addition families were contacted and medical records were requested from referring hospitals. Main outcome. Pregnancies with ≥1 surviving infants after FLOC treatment categorised according to stage of TTTS. Results. In 75% of pregnancies ≥1 infant was born alive. At stage I both infants survived in one pregnancy and one survived in the second. There was no significant difference between cases at stage II or III, i.e. 73% vs. 78% resulted in ≥1 surviving infant. At stage IV 66% ended with ≥1 surviving infant. Conclusion. Treatment of TTTS is feasible in a rather small country like Sweden with comparable results to other centres. There are strong arguments for centralisation and further improvement of this kind of highly specialised treatment.
Authors:
Sverker Ek; Cecilia Pegelow Halvorsen; Marius Kublickas; The-Hung Bui; Annika Dellgren; Nikos Papadogiannakis; Eleonor Tiblad; Elle Wågström; Magnus Westgren
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-9
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
1Karolinska Institutet, Center of Fetal Medicine, Department of Obstetrics and Gynecology, Karolinska Univ. Hospital, Stockholm, Sweden 2Dept of Obstetrics and Gynecology, Södersjukhuset, Stockholm, Sweden, and 3Karolinska Institute, Dept of Pathology, Karolinska Univ. Hospital, Stockholm, Sweden.
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