Document Detail

Establishing functional residual capacity at birth: the effect of sustained inflation and positive end-expiratory pressure in a preterm rabbit model.
MedLine Citation:
PMID:  19190537     Owner:  NLM     Status:  MEDLINE    
The effect of a 20 s sustained inflation (SI) and positive end-expiratory pressure (PEEP) on functional residual capacity (FRC) formation at birth were investigated. Preterm rabbit pups (28 d) were randomized at birth into four groups (n = 6 for each): 1) SI, PEEP 5 cm H2O, 2) no SI, PEEP 5 cm H2O, 3) no SI + no PEEP, 4) SI + no PEEP. FRC and tidal volume (Vt) were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging. Ventilation with a SI and PEEP uniformly aerated the lung and Vt and FRC were recruited by the first tidal inflation. Ventilation without a SI, with PEEP, gradually recruited Vt and FRC with each inflation but aeration was not uniform. Ventilation without a SI or PEEP, gradually recruited Vt, but no FRC. Ventilation with a SI, without PEEP, uniformly aerated the lung and recruited Vt but no FRC. FRC was greater with SI (p = 0.006) during the first minute, but was larger with PEEP than without PEEP throughout the first 7 min (p < 0.0005). Effects of PEEP and SI were additive. In ventilated preterm rabbits at birth, combining a SI and PEEP improved FRC formation and uniformity of lung aeration, but PEEP had the greatest influence.
Arjan B te Pas; Melissa Siew; Megan J Wallace; Marcus J Kitchen; Andreas Fouras; Robert A Lewis; Naoto Yagi; Kentaro Uesugi; Susan Donath; Peter G Davis; Colin J Morley; Stuart B Hooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  65     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  IM    
Neonatal Services, Royal Women's Hospital, Melbourne, Victoria 3052, Australia.
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MeSH Terms
Animals, Newborn
Functional Residual Capacity*
Gestational Age
Lung / physiopathology*,  radiography
Models, Animal
Positive-Pressure Respiration*
Premature Birth / physiopathology,  radiography,  therapy*
Pulmonary Ventilation*
Respiration, Artificial / methods*
Tidal Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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