Document Detail

Establishing consensus criteria for the diagnosis of diabetes in pregnancy following the HAPO study.
MedLine Citation:
PMID:  20840258     Owner:  NLM     Status:  MEDLINE    
The current diagnostic criteria for gestational diabetes mellitus are controversial because they lack correlation to maternal and perinatal outcome. The results of the hyperglycemia and adverse pregnancy outcome (HAPO) study demonstrate a linear association between increasing levels of fasting, 1- and 2-h plasma glucose post a 75 g oral glucose tolerance test to several significant outcome endpoints, such as birth weight above the 90th percentile, cord blood serum C-peptide level above the 90th percentile, primary cesarean delivery, clinical neonatal hypoglycemia, premature delivery, shoulder dystocia or birth injury, intensive neonatal care admission, hyperbilirubinemia, and preeclampsia. A consensus report by the IADPSG, based on a vigorous assessment of the HAPO results and other studies, recommended an endorsement of risk-based, internationally accepted criteria for the diagnosis and classification of diabetes in pregnancy. This review follows the steps from defining the problem to the endpoint of achieving a worldwide policy change.
Eran Hadar; Moshe Hod
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1205     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2010-09-28     Revised Date:  2010-10-19    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  IM    
Copyright Information:
© 2010 New York Academy of Sciences.
Perinatal Division, Helen Schneider's Hospital for Women, Rabin Medical Center, Petah-Tiqva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Blood Glucose / analysis
Diabetes, Gestational / blood,  diagnosis*
Glucose Tolerance Test
Hyperglycemia / blood,  complications,  diagnosis
Pregnancy Complications / blood,  diagnosis
Pregnancy Outcome
Reg. No./Substance:
0/Blood Glucose

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