Document Detail

Established histological identity and cell destruction treatments for cancer.
MedLine Citation:
PMID:  11021319     Owner:  NLM     Status:  MEDLINE    
During cancerous cell turnover activity maintained by two types of mitosis, maturation and heteroduplication, cancer tissue consists of two types of cells, maturable and non-maturable. Most of the tissue is composed of maturable cells, which eventually disappear in the terminally matured cell phase. These cells do not participate in cell turnover activity or the organoid identity of cancer tissue. However, a small portion of the tissue is comprised of non-maturable cells, which replicate themselves endlessly, while producing maturable cells through each mitotic division in hetero-duplication mitosis. Thus, cell turnover activity and organoid identity are established in the cancer tissue. This organoid identity is solely responsible for carcinogenesis. Since most typical features of cancer are only detectable in maturable cells during maturation mitosis, cell destruction targeting these features should not be regarded as eradication. To eradicate cancer, the organoid identity of cancer, which is only established by heteroduplication mitosis, should clearly be recognized, and a new concept of cancer treatment based on destruction of the organoid identity should be devised in the future. This does not appear to be an insurmountable task.
Y Hirata; S Hirata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  55     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Hirata Hospital, Kochi, Japan.
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MeSH Terms
Cell Differentiation
Cell Division
Models, Biological
Neoplasm Metastasis
Neoplasms / pathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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