Document Detail


Established histological identity and cell destruction treatments for cancer.
MedLine Citation:
PMID:  11021319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During cancerous cell turnover activity maintained by two types of mitosis, maturation and heteroduplication, cancer tissue consists of two types of cells, maturable and non-maturable. Most of the tissue is composed of maturable cells, which eventually disappear in the terminally matured cell phase. These cells do not participate in cell turnover activity or the organoid identity of cancer tissue. However, a small portion of the tissue is comprised of non-maturable cells, which replicate themselves endlessly, while producing maturable cells through each mitotic division in hetero-duplication mitosis. Thus, cell turnover activity and organoid identity are established in the cancer tissue. This organoid identity is solely responsible for carcinogenesis. Since most typical features of cancer are only detectable in maturable cells during maturation mitosis, cell destruction targeting these features should not be regarded as eradication. To eradicate cancer, the organoid identity of cancer, which is only established by heteroduplication mitosis, should clearly be recognized, and a new concept of cancer treatment based on destruction of the organoid identity should be devised in the future. This does not appear to be an insurmountable task.
Authors:
Y Hirata; S Hirata
Related Documents :
21571619 - Albumin-bound paclitaxel: the benefit of this new formulation in the treatment of vario...
18539959 - Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy.
18371389 - Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a ne...
6472019 - Goblet cells in the laryngeal mucosa in cancer of the larynx.
20699369 - Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimul...
11708489 - Functionality of circulating dna: the hypothesis of genometastasis.
23463659 - Association of cancer with moderately impaired renal function at baseline in a large, r...
23837649 - High-resolution imaging mass spectrometry reveals detailed spatial distribution of phos...
19087469 - Excess cancer mortality in psychiatric patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  55     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Affiliation:
Hirata Hospital, Kochi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Differentiation
Cell Division
Humans
Mitosis
Models, Biological
Neoplasm Metastasis
Neoplasms / pathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mass flux balance-based model and metabolic flux analysis for collagen synthesis in the fibrogenesis...
Next Document:  Gout attacks and lunar cycle.