Document Detail

Established and evolving medical therapies for claudication in patients with peripheral arterial disease.
MedLine Citation:
PMID:  17063165     Owner:  NLM     Status:  MEDLINE    
Claudication resulting from peripheral arterial disease causes substantial impairment in the ability to carry out normal daily activities. The medical treatments for claudication that are currently available are exercise rehabilitation and one drug, cilostazol. Pentoxifylline, which improves red cell deformability, lowers fibrinogen levels and decreases platelet aggregation, has been used historically, but frequency of use has declined because of limited effectiveness. Exercise rehabilitation, while efficacious, has been underused in the past. This therapy is, however, currently the subject of several large research projects. These studies are investigating mechanisms by which exercise therapy could benefit people with claudication and are also directly comparing it with other therapies. Concurrently, several new drug therapies for claudication are in the process of being evaluated. These research efforts might increase the available armamentarium and thereby help to alleviate the impairments associated with this symptom. The aim of this article is to discuss the current medical treatments being developed for use in patients with claudication resulting from peripheral arterial disease.
Judith G Regensteiner; Kerry J Stewart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  3     ISSN:  1743-4300     ISO Abbreviation:  Nat Clin Pract Cardiovasc Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2006-11-24     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  604-10     Citation Subset:  IM    
Section of Vascular Medicine, Divisions of General Internal Medicine and Cardiology, University of Colorado Health Sciences Center, Box B-180, 4200 E 9th Avenue, Denver, CO 80262, USA.
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MeSH Terms
Ankle / blood supply*
Arterial Occlusive Diseases / complications,  drug therapy,  physiopathology,  therapy*
Blood Pressure
Brachial Artery / physiopathology*
Exercise Test
Exercise Therapy*
Hematologic Agents / therapeutic use*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Intermittent Claudication / drug therapy,  etiology,  physiopathology,  therapy*
Pentoxifylline / therapeutic use
Peripheral Vascular Diseases / complications,  drug therapy,  physiopathology,  therapy*
Randomized Controlled Trials as Topic
Tetrazoles / therapeutic use
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Hematologic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Tetrazoles; 0/Vasodilator Agents; 6493-05-6/Pentoxifylline; N7Z035406B/cilostazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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