Document Detail


Established and emerging biological activity markers of inflammatory bowel disease.
MedLine Citation:
PMID:  10685736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assessment of disease activity in inflammatory bowel disease (IBD), i.e., ulcerative colitis (UC) and Crohn's disease (CD), is done using clinical parameters and various biological disease markers. Ideally, a disease marker must: be able to identify individuals at risk of a given disorder, be disease specific, mirror the disease activity and, finally, be easily applicable for routine clinical purposes. However, no such disease markers have yet been identified for IBD. In this article, classical disease markers including erythrocyte sedimentation rate, acute phase proteins (especially orosomucoid and CRP), leukocyte and platelet counts, albumin, neopterin, and beta2-microglobulin will be reviewed together with emerging disease markers such as antibodies of the ANCA/ASCA type, cytokines (e.g., IL-1, IL-2Ralpha, IL-6, IL-8, TNF-alpha, and TNF-alpha receptors) and with various adhesion molecules. It is concluded that none of the pertinent laboratory surrogate markers of disease activity in IBD are specific or sensitive enough to replace basic clinical observation such as the number of daily bowel movements, general well-being, and other parameters in parallel. Further studies are highly warranted to identify and assess the clinical importance and applicability of new laboratory markers for the diagnosis or the disease activity of IBD.
Authors:
O H Nielsen; B Vainer; S M Madsen; J B Seidelin; N H Heegaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  95     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-08     Completed Date:  2000-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-67     Citation Subset:  IM    
Affiliation:
Department of Medicine CF, Glostrup Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis
Antibodies / blood
Antibodies, Antineutrophil Cytoplasmic / blood
Biological Markers / analysis*,  blood
Blood Sedimentation
Cell Adhesion Molecules / blood
Humans
Inflammatory Bowel Diseases / diagnosis*,  physiopathology
Interleukins / blood
Leukocyte Count
Mannans / immunology
Neopterin / blood
Phosphopeptides / immunology
Platelet Count
Risk Factors
Serum Albumin / analysis
Tumor Necrosis Factor-alpha / analysis
beta 2-Microglobulin / blood
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Antibodies; 0/Antibodies, Antineutrophil Cytoplasmic; 0/Biological Markers; 0/Cell Adhesion Molecules; 0/Interleukins; 0/Mannans; 0/Phosphopeptides; 0/Serum Albumin; 0/Tumor Necrosis Factor-alpha; 0/beta 2-Microglobulin; 0/phosphopeptidomannan; 670-65-5/Neopterin
Comments/Corrections
Comment In:
Am J Gastroenterol. 2000 Jul;95(7):1849-50   [PMID:  10926011 ]

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